讲座题目:Tyrosine Kinases in Innate Sensing of Damage and Invasion
讲座人:徐平龙教授,浙江大学生命科学研究院教授、资深研究员、博导
时间:2019年1月14日15:00
地点:威尼斯wnsr666金光生命科学大楼411
联系人:蒋争凡教授,电话57923
讲座摘要:
Innate sensing of cytosolic RNA/DNA warns host cells both microbe invasion and cellular damage, and to initiate counter measures by igniting cascades through MAVS/STING-TBK1-IRF3 axis and NF-κB. Yet, how the magnitude of this recently defined innate immune sensing is controlled remains largely unknown. Through functional screens of proteomics and analyses of interactome, we defined a few interesting players, particularly the tyrosine kinases, in governing of cytosolic nucleic acid sensing. These findings identify some physiological regulators of innate immune sensing and reveal an intriguing interplay between classical oncogenic pathway and danger sensing, which may benefit the development of new prevention strategies against both pathogen infection and tumorigenesis.
报告人简介:
徐平龙博士,98年本科毕业于四川大学,03年博士毕业于中科院上海生化与细胞所。04年起在美国UCSF进行博士后研究,之后担任UCSF研究助理教授,至13年夏受聘于浙江大学。实验室采用多学科交叉手段,致力于阐明核酸天然免疫识别的微环境调控和信号终止机制,及其在宿主防御、细胞衰老和抗肿瘤免疫等重要生物学进程中的功能与分子基础。研究进展以通讯作者发表于Nat Cell Biol、Cell Host Microbe、Genes Dev、Mol Cell等知名学术期刊,并多次被领域国际专家在 Nat Cell Biol、Mol Cell、Sci Signal等期刊撰写专文评述。17年获国家杰出青年科学基金资助,18年获国家自然科学基金重点项目资助,并获得吴瑞纪念基金会顾孝诚讲座奖、浙江大学求是特聘教授、浙江大学优博导师等学术荣誉。
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