威尼斯wnsr666学术报告
题目：Abnormal behavior reveals a role for the Drosophila transcription factor Lov in endopolyploid growth
报告人：KATHLEEN MARY BECKINGHAM, PhD
Professor,
Department of Biochemistry and Cell Biology, 
Rice University
时间：2017年10月24日（星期二）1：30-2：30pm
地点：金光生命科学大楼411会议室
主持人：伊成器
摘要：
Our search for mutations that affect gravitational responses in Drosophila identified several novel genes. These genes were named after astronauts in recognition of our support from NASA. One of these genes, named jim lovell (lov), encodes a transcription factor of the BTB/POZ family. lov is expressed in many subsets of neurons and lov mutations affect several types of behavior. However, lov has proved to have other unexpected roles. The massive growth of Drosophila larvae is associated with endopolyploid growth rather than growth through mitosis. An unusual larval behavior associated with lov RNAi knockdown has led to the finding that lov is required for this endopolyploid growth. Our work on dissecting the molecular basis of this role for lov will be discussed. 
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