威尼斯wnsr666年度特邀学术报告
题目：Chemically induced pluripotent stem cells
报告人：邓宏魁
威尼斯wnsr666特聘教授
时间：2013年11月8日（周五）下午13:00-14:30 PM
地点：威尼斯wnsr666新生物楼101报告厅
Understanding the establishment of cellular identity is a major goal of modern biology. Programming and reprogramming cellular identity elicits tremendous scientific and public interest. The groundbreaking work of Takahashi and Yamanaka in 2006 established a landmark in cellular reprogramming with the generation of induced pluripotent stem cells (iPSCs) by forced expression of just four transcription factors. Similar to embryonic stem cells, iPSCs can proliferate and self-renew indefinitely under appropriate conditions and give rise to all cell types in the body, which gives these cells great potential for use in regenerative medicine. I will present a new strategy that can easily generate iPSCs from adult somatic cells using only a chemical cocktail, a procedure that is termed “chemical reprogramming”. Our study provides an important proof-of-principle demonstration that manipulation of signaling pathways and chromatin structure alone are sufficient to endow cells with pluripotency. This finding may lead to a safe and simple way to generate patient-specific iPSCs without the need for viral infection or introduction of other transgenes.
欢迎各位老师和同学积极参加！