威尼斯wnsr6662017年度秋季学期学术系列讲座之十四
题目：Optical electrophysiology: from microbes to mice
讲座人：Adam E. Cohen, Ph.D
Professor
Howard Hughes Medical Institute
Harvard University
时间：2017年12月29日（星期五），13:00-14:30
地点：威尼斯wnsr666邓祐才报告厅
主持人：李毓龙
摘要：
Every lipid bilayer is an electrical insulator, and charge imbalances between its faces can lead to a membrane voltage.  Voltage modulates many transmembrane transport processes, and membrane voltage is dynamically regulated in most cell types--most famously in neurons and cardiac cells, but also in bacteria, plants, and intracellular organelles.  Membrane voltage is very hard to measure because it is not directly visible.  We have developed fluorescent protein reporters of membrane potential, and associated instrumentation for high-speed voltage imaging.  I will describe some new tools for all-optical electrophysiology, and illustrate with examples of measurements in bacteria, fish, and in the brains of behaving mice.
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