威尼斯wnsr6662018年度秋季学期学术系列讲座之三
题目：Feeling force with the mechanosensitive Piezo channels
讲座人：Bailong Xiao, PhD
Principal Investigator, Associate Professor
State Key Laboratory of Membrane Biology;
Tsinghua-Peking Joint Center for Life Sciences; IDG/McGovern Institute for Brain Research;
School of Pharmaceutical Sciences, Tsinghua University
Tsinghua University
时间：2018年10月12日（星期五），13:00-14:30
地点：威尼斯wnsr666邓祐才报告厅
主持人：高宁教授
摘要：
The evolutionarily conserved Piezo family of proteins forms the long-sought bona fide mammalian mechanosensitive cation channel, and plays critical roles in various mechanotransduction processes such as touch, proprioception, vascular development and blood pressure regulation. Mammalian Piezo proteins contain over 2500 amino acids with 30-40 predicted transmembrane segments (TM), and do not bear sequence homology with any known class of ion channels. These features make their structure-function studies and drug discovery challenging. Taking a multidisciplinary approach combining protein engineering and purification, cryo-EM, electrophysiology, drug screening and mouse genetics, we aim to understand how the mechanosensitive Piezo channels serve as effective mechanotransducers for converting mechanical force into electrochemical signals, and how their mechanosensitivity and ion permeation properties precisely control various biological processes involving mechanotransduction. In this talk, I will present our recent progress in revealing the structure, ion-permeation, mechanogating, molecular and pharmacological regulation mechanisms of the Piezo channels.
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